As a result, adenylate cyclase is locked into an active form through inhibition of an inherent feed-back regulatory mechanism which normally involves the hydrolysis of GTP to GDP and Pi.
Four sections of mucosa were prepared as such from the one animal, and mounted in Lucite Ussing chambers of aperture 1. Once the tissue was mounted and prior to experimentation, the I SC was determined at approximately 10 min. Westphal, U. Other orally administrable formulations include syrups, elixirs, and hard and soft gelatin capsules, which may also be enteric-coated.
These molecules stimulate secretion by action on the cAMP pathway. Hsu, L.
A vast accumulation of knowledge has been attained on the mechanisms of attachment and role of enterotoxins in pathogenesis of enterotoxigenic Escherichia coli ETEC infections.
Figs contain the enzyme ficin, which is a proteolytic enzyme able to metabolize protein into amino acids. CH Ref legal event code: Internal signals within cells are carried by "second messengers". This finding suggests that stem bromelain protease is responsible for the anti-diarrhoea action of bromelain. It is hypothesised that these enzymes have an additional mechanism for inhibiting fluid secretion since they appear to inhibit secretion induced by prostaglandin E 2 and by other secretagogues that do not interact with cellular receptors, namely theophylline, 8-Br-cGMP, 8-Br-cAMP and Ca-ionophore.
NZ253748A en. The data also reveal that treatment of intestinal tissue increases the absorption of nutrients. The occasional cells that may have been affected by bromelain treatment, therefore did not appear to adversely affect the absorptive capacity of the tissue.
Adenylate cyclase activity is stimulated following catalysing the NAD-dependent cyclase complex. Retinol inhibition of ficin was partially reversible.
However, the significant point about these observations is that enzymes such as bromelain and stem bromelain protease will inhibit secretion caused by secretagogues which cause diarrhoea by different mechanisms. Carotene and retinol inhibited ficin and cathepsin D to similar extents. Ref document number: Experiments were conducted in a similar manner to that described above.
This process is experimental and the keywords may be updated as the learning algorithm improves. Figs are thought to have originated in either western Asia or northern Asia Minor before being widely cultivated in countries in the Middle East and bordering the Mediterranean Sea.
Briefly, the B protomer binds to a ganglioside receptor GM1 [galactosyl-N-acetylgalactosaminyl- N-acetylneuraminyl galactosylglucosylceramide] located on the brush border membrane. Control tissues were treated with PBS alone.
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Date of ref document: CA2137674A1 en.